Global infection and mortality rates have soared to millions due to SARS-CoV-2 human-to-human transmission via droplets which then declared as pandemic. This study examined the created cold plasma equipment (CPE) effectiveness in reducing COVID-19 transmission in a confined space. CPE sucked air using a fan in a test chamber then pushed it into a cold plasma reactor. The results indicated that it was able to terminate all SARS-CoV-2 variants along with bacteria and fungi indoors by keeping it turned on for 30 min’ minimum. CPE was proven as safe and effective to hinder virus transmission with the acceptable ozone emission as the side effect.